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The protein apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/REF-1) negatively regulates Nrf2 through its redox activity, with inhibition of APE1/REF-1 causing significant increases in the levels of Nrf2 and selected target genes HMOX1, GCLC , and GCLM in pancreatic cancer cell lines without causing the generation of ROS [323]

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Use caution when making any direct comparisons due to differences in DMT dosing schedules and pharmacodynamics 2